李瑞文章正式版在线

作者: 时间:2018-06-05

Congratulations to Li Rui, Dr. Zou, Jianyong and all.

Zou M#, Li R#, Wang JY, Wang K, Wang YN, Li Y, Ji FX, Sun SN, Huang SS, Fan HH, Huang CP, Zhang X*, Zhu JH*. Association analyses of variants of SIPA1L2, MIR4697, GCH1, VPS13C and DDRGK1 with Parkinson's disease in East Asians. Neurobiol. Aging, 2018, 68: 159.e7-159.e14 10.1016/j.neurobiolaging.2018.03.005

Free link (good till July 25 2018) https://authors.elsevier.com/a/1XA6NivP72VEa

Abstract

A recent large-scale European-originated genome-wide associationdata meta-analysis followed by a replication study identified 6 new risk loci for Parkinson's disease (PD), which include rs10797576/SIPA1L2, rs117896735/INPP5F, rs329648/MIR4697, rs11158026/GCH1, rs2414739/VPS13C, and rs8118008/DDRGK1. However, whether these new loci are associated with PD in Asian populations remain elusive. The INPP5F is nonpolymorphic in Asians. The present study aimed to understand the effects of the other 5 new loci in a Han Chinese population comprising 579 sporadic PD patients and 642 controls. Significant associations with PD were observed in the variants of SIPA1L2 (p= 0.001) andVPS13C (p= 0.007), where the T (odd ratio [OR] = 1.484, 95% confidence interval [CI] 1.186–1.858) and A (OR = 1.362, 95% CI 1.087–1.707) alleles serve as the risk alleles, respectively. The genotype distributions in the SIPA1L2 andVPS13C variants were also different between the patients and controls (p= 0.002 and p= 0.023, respectively). In contrast, no significant association with PD was found in the variants of MIR4697GCH1, and DDRGK1 either in allele or genotype frequencies. Noteworthy, a followed meta-analysis of East Asian studies suggested an association of the GCH1 variant with PD (p= 0.04, OR 1.08, 95% CI 1.00–1.16), while the other results are in line with those of our cohort. In conclusion, our study together with meta-analyses demonstrates that the variants of SIPA1L2 andVPS13C, potentially GCH1, but not of MIR4697 and DDRGK1, are associated with PD susceptibility in East Asians.

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